Tumor necrosis factor/cachectin is a less potent inducer of serum amyloid A synthesis than interleukin 1.

Serum amyloid A (SAA) gene expression is known to be induced by interleukin (IL-1). The time course of in vivo induction of SAA synthesis by IL-1 was found to vary according to dose, in that SAA concentration was maximal at 6 hours following lower doses of IL-1, but greater at 20 hours when higher (greater than 500 ng) doses were administered. Because of… CONTINUE READING