Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.

@article{Fukumura2010TumorMA,
  title={Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.},
  author={Dai Fukumura and Dan G Duda and Lance L. Munn and Rakesh K. Jain},
  journal={Microcirculation},
  year={2010},
  volume={17 3},
  pages={
          206-25
        }
}
Intravital imaging techniques have provided unprecedented insight into tumor microcirculation and microenvironment. For example, these techniques allowed quantitative evaluations of tumor blood vasculature to uncover its abnormal organization, structure and function (e.g., hyper-permeability, heterogeneous and compromised blood flow). Similarly, imaging of functional lymphatics has documented their absence inside tumors. These abnormalities result in elevated interstitial fluid pressure and… CONTINUE READING

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