Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.

Abstract

BACKGROUND Colon cancers with high-frequency microsatellite instability have clinical and pathological features that distinguish them from microsatellite-stable tumors. We investigated the usefulness of microsatellite-instability status as a predictor of the benefit of adjuvant chemotherapy with fluorouracil in stage II and stage III colon cancer. METHODS… (More)
DOI: 10.1056/NEJMoa022289

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@article{Ribic2003TumorMS, title={Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.}, author={Christine M. Ribic and Daniel J. Sargent and Malcolm J. Moore and Stephen N. Thibodeau and Amy J. French and Richard M. Goldberg and Stanley R. Hamilton and Pierre Laurent-Puig and Robert Gryfe and Lois E. Shepherd and Dongsheng Tu and Mark S. Redston and Steven Gallinger}, journal={The New England journal of medicine}, year={2003}, volume={349 3}, pages={247-57} }