Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.

@article{Ribic2003TumorMS,
  title={Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.},
  author={Christine M. Ribic and Daniel J. Sargent and Malcolm J. Moore and Stephen N. Thibodeau and Amy J. French and Richard M. Goldberg and Stanley R. Hamilton and Pierre Laurent-Puig and Robert Gryfe and Lois E. Shepherd and Dongsheng Tu and Mark Redston and Steven Gallinger},
  journal={The New England journal of medicine},
  year={2003},
  volume={349 3},
  pages={247-57}
}
BACKGROUND Colon cancers with high-frequency microsatellite instability have clinical and pathological features that distinguish them from microsatellite-stable tumors. We investigated the usefulness of microsatellite-instability status as a predictor of the benefit of adjuvant chemotherapy with fluorouracil in stage II and stage III colon cancer. METHODS Tumor specimens were collected from patients with colon cancer who were enrolled in randomized trials of fluorouracil-based adjuvant… CONTINUE READING
Highly Influential
This paper has highly influenced 40 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS