Tumor microenvironment macrophage inhibitory factor directs the accumulation of interleukin-17-producing tumor-infiltrating lymphocytes and predicts favorable survival in nasopharyngeal carcinoma patients.

@article{Li2012TumorMM,
  title={Tumor microenvironment macrophage inhibitory factor directs the accumulation of interleukin-17-producing tumor-infiltrating lymphocytes and predicts favorable survival in nasopharyngeal carcinoma patients.},
  author={Jiang Li and Hao-yuan Mo and Geng Xiong and Lin Zhang and Jia He and Zhou-feng Huang and Zhi-Wei Liu and Qian Chen and Zi-Ming Du and Li-Ming Zheng and Chao-nan Qian and Yi-xin Zeng},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 42},
  pages={35484-95}
}
The accumulation of an intratumoral CD4(+) interleukin-17-producing subset (Th17) of tumor-infiltrating lymphocytes (TILs) is a general characteristic in many cancers. The relationship between the percentage of Th17 cells and clinical prognosis differs among cancers. The mechanism responsible for the increasing percentage of such cells in NPC is still unknown, as is their biological function. Here, our data showed an increase of Th17 cells in tumor tissues relative to their numbers in normal… CONTINUE READING