Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism.

  title={Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism.},
  author={Hongyun Zhao and Lifeng Yang and Joelle Baddour and Abhinav Achreja and Vincent Bernard and Tyler J. Moss and Juan C. Marini and Thavisha Tudawe and Elena G. Seviour and F Anthony San Lucas and Hector A. Olvera Alvarez and Sonal Gupta and Sourindra N. Maiti and Laurence J. N. Cooper and Donna M. Peehl and Prahlad T. Ram and Anirban Maitra and Deepak Nagrath},
Cancer-associated fibroblasts (CAFs) are a major cellular component of tumor microenvironment in most solid cancers. Altered cellular metabolism is a hallmark of cancer, and much of the published literature has focused on neoplastic cell-autonomous processes for these adaptations. We demonstrate that exosomes secreted by patient-derived CAFs can strikingly reprogram the metabolic machinery following their uptake by cancer cells. We find that CAF-derived exosomes (CDEs) inhibit mitochondrial… CONTINUE READING
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actin filaments formed during platelet shape change. Nature 293:302–305

  • HC Christianson, KJ Svensson, TH van Kuppevelt, J-P Li, M. Belting
  • 2013
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