Tumor metastasis to brain: role of endothelial cells, neurotrophins, and paracrine growth factors.

@article{Nicolson1994TumorMT,
  title={Tumor metastasis to brain: role of endothelial cells, neurotrophins, and paracrine growth factors.},
  author={Garth L. Nicolson and David G. Menter and John L. Herrmann and Philip G. Cavanaugh and L Jia and J-i Hamada and Zhong Yun and Motowo Nakajima and Dario Marchetti},
  journal={Critical reviews in oncogenesis},
  year={1994},
  volume={5 5},
  pages={451-71}
}
An important clinical endpoint in patients with cancer is formation of metastases in the brain. Understanding this phenomenon is important in several types of malignancies, including melanoma, lung and breast cancers. Metastatic tumor cells use specific adhesion molecules to home to brain, and there they must attach to microvessel endothelial cells and respond to brain endothelial cell-derived motility factors and brain invasion factors to invade the CNS. Neurotrophins are important invasion… CONTINUE READING
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