Tumor metastasis is not due to adaptation of cells to a new organ environment.

@article{Nicolson1982TumorMI,
  title={Tumor metastasis is not due to adaptation of cells to a new organ environment.},
  author={Garth L. Nicolson and Susan E. Custead},
  journal={Science},
  year={1982},
  volume={215 4529},
  pages={
          176-8
        }
}
Murine B16 melanoma cells were adapted for lung survival and growth by allowing them to attach to Bio-Carrier beads and injecting the beads intravenously into normal mice. The beads lodged mechanically in the microcirculation of the lung. When the melanoma cells had grown into visible tumors from the arrested beads, the tumors were removed and the cells were dispersed, cultured to remove normal cells, and reattached to new beads. The process was repeated nine times. Previously another B16… CONTINUE READING
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