Tumor-mediated inhibition of human dendritic cell differentiation and function is consistently counteracted by combined p38 MAPK and STAT3 inhibition

@inproceedings{Oosterhoff2012TumormediatedIO,
  title={Tumor-mediated inhibition of human dendritic cell differentiation and function is consistently counteracted by combined p38 MAPK and STAT3 inhibition},
  author={Dinja Oosterhoff and Sin{\'e}ad. M. Lougheed and Rieneke van de Ven and Jelle J. Lindenberg and Hester van Cruijsen and Lotte Hiddingh and Jan Kroon and Alfons J. M. van den Eertwegh and Basav N. Hangalapura and Rik J. Scheper and Tanja D. de Gruijl},
  booktitle={Oncoimmunology},
  year={2012}
}
Targeting dendritic cells (DC) through the release of suppressive factors is an effective means for tumors to escape immune control. We assessed the involvement of downstream signaling through the JAK2/STAT3 and p38 MAPK pathways in tumor-induced suppression of human DC development. Whereas the JAK2/STAT3 pathway has been pinpointed in mouse studies as a key regulator of myeloid suppression, in human DC this is less well established. We studied the effects of STAT3 inhibition on the suppression… CONTINUE READING

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Cross-talk between tumor and myeloid cells: how to tip the balance in favor of antitumor immunity

  • JJ Lindenberg, CM Fehres, H van Cruijsen, D Oosterhoff, TD. de Gruijl
  • Immunotherapy
  • 2011
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