Tumor lysis syndrome and acute kidney injury: evaluation, prevention, and management.

@article{AbuAlfa2010TumorLS,
  title={Tumor lysis syndrome and acute kidney injury: evaluation, prevention, and management.},
  author={Ali K. Abu-Alfa and Anas Younes},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2010},
  volume={55 5 Suppl 3},
  pages={
          S1-13; quiz S14-9
        }
}
Tumor lysis syndrome (TLS) describes a constellation of biochemical and clinical abnormalities resulting from rapid and massive tumor cell death. TLS is frequently associated with hyperuricemia, hyperkalemia, hyperphosphatemia, and secondary hypocalcemia that may lead to serious clinical complications, including acute kidney injury and cardiac arrest. Identification of tumor- and patient-specific risk factors for TLS and early recognition of laboratory and clinical TLS based on established… CONTINUE READING
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