Tumor lymphangiogenesis and melanoma metastasis.

  title={Tumor lymphangiogenesis and melanoma metastasis.},
  author={Matthias Rinderknecht and Michael Detmar},
  journal={Journal of cellular physiology},
  volume={216 2},
Malignant melanomas of the skin primarily metastasize to lymph nodes, and the detection of sentinel lymph node metastases serves as an important prognostic parameter. There is now compelling evidence that melanomas can induce lymphangiogenesis (growth of lymphatic vessels), mainly at the tumor-stroma interface, and that the level of tumor lymphangiogenesis is correlated with the incidence of sentinel lymph node metastases and with disease-free survival. Thus, tumor lymphangiogenesis can serve… CONTINUE READING