Tumor lymphangiogenesis and lymphangiogenic growth factors.

  title={Tumor lymphangiogenesis and lymphangiogenic growth factors.},
  author={Ming-xu Da and Zhuang Wu and Hong-wei Tian},
  journal={Archives of medical research},
  volume={39 4},
Recent studies have revealed that malignant tumors can actively induce the formation of new lymphatic vessels and metastasize through the lymphatic system. Tumor-induced lymphangiogenesis driven by tumors expressed lymphangiogenic growth factors such as VEGF family, fibroblast growth factor 2 (FGF-2), angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and platelet-derived growth factors (PDGFs) is correlated with lymph node metastasis in experimental cancer models and in several types of human… CONTINUE READING
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