Tumor localization and in vivo antitumor activity of the immunoconjugate composed of anti-human colon cancer monoclonal antibody and mitomycin C-dextran conjugate.

Abstract

The tissue distribution and in vivo antitumor activity of a novel monoclonal antibody-mitomycin C conjugate (A7-MMCD) composed of anti-human MAb A7 and MMC-dextran conjugate were investigated using tumor-bearing mice. A7-MMCD was prepared via an anionic dextran intermediate for the purpose of keeping the non-specific uptake by the reticuloendothelial system… (More)

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@article{Noguchi1991TumorLA, title={Tumor localization and in vivo antitumor activity of the immunoconjugate composed of anti-human colon cancer monoclonal antibody and mitomycin C-dextran conjugate.}, author={Atsuko Noguchi and T. Takahashi and T. Yamaguchi and K. Kitamura and Y. Takakura and Mitsuru Hashida and Hitoshi Sezaki}, journal={Japanese journal of cancer research : Gann}, year={1991}, volume={82 2}, pages={219-26} }