Tumor inhibition, persistence, and binding of actinomycin D in mouse skin.

Abstract

Actinomycin D (AMD) inhibits tumor induction by 63% when applied as late as 31 days after single treatment with 7,12-dimethylbenz [a] anthracene and 90 days prior to repeated treatment with the tumor-promoting agent phorbol myristate acetate in two-stage carcinogenesis on mouse skin. Inhibition was 61% when AMD was applied 90 days after 7,12-dimethylbenz [a] anthracene and 14 days prior to phorbol myristate acetate. The persistence of AMD in skin was studied with female ICR/Ha Swiss mice. AMD applied to the dorsal skin was isolated and identified as late as 6 days after application. When actinomycin D-methyl-14C (AMD-14C) was

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Cite this paper

@article{Segal1972TumorIP, title={Tumor inhibition, persistence, and binding of actinomycin D in mouse skin.}, author={A. Segal and T Honohan and Mette Schroeder and Carol Katz and B. L. Van Duuren}, journal={Cancer research}, year={1972}, volume={32 7}, pages={1384-90} }