Tumor infiltrating lymphocytes in melanoma comprise high numbers of T-cell clonotypes that are lost during in vitro culture.

@article{Straten2000TumorIL,
  title={Tumor infiltrating lymphocytes in melanoma comprise high numbers of T-cell clonotypes that are lost during in vitro culture.},
  author={Per Thor Straten and Alexei F. Kirkin and Elsebeth Siim and Karin Dahlstr{\"o}m and Krzysztof Tadeusz Drzewiecki and Tina Seremet and Jesper Zeuthen and J{\"u}rgen C Becker and Per Guldberg},
  journal={Clinical immunology},
  year={2000},
  volume={96 2},
  pages={94-9}
}
Melanoma is generally accepted as being an antigenic tumor capable of eliciting T-cell responses that, however, in most cases are inadequate to control tumor growth. Tumor-infiltrating lymphocytes (TIL) in melanoma lesions comprise clonotypic T cells, indicating the in situ recognition of melanoma-associated peptide epitopes. Cultured TIL have been studied in order to unveil characteristics of TIL and the interactions of TIL and melanoma cells. Whether in vitro cultured TIL mirrors the in situ… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…