Tumor-infiltrating lymphocytes are correlated with response to neoadjuvant chemotherapy in triple-negative breast cancer

@article{Ono2011TumorinfiltratingLA,
  title={Tumor-infiltrating lymphocytes are correlated with response to neoadjuvant chemotherapy in triple-negative breast cancer},
  author={Makiko Ono and Hitoshi Tsuda and Chikako Shimizu and Sohei Yamamoto and Tatsuhiro Shibata and Harukaze Yamamoto and Taizo Hirata and Kan Yonemori and Masashi Ando and Kenji Tamura and Noriyuki Katsumata and Takayuki Kinoshita and Yuichi Takiguchi and Hideki Tanzawa and Yasuhiro Fujiwara},
  journal={Breast Cancer Research and Treatment},
  year={2011},
  volume={132},
  pages={793-805}
}
The purpose of the present study was to identify histological surrogate predictive markers of pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in triple-negative breast cancer (TNBC). Among 474 patients who received NAC and subsequent surgical therapy for stage II–III invasive breast carcinoma between 1999 and 2007, 102 (22%) had TNBC, and 92 core needle biopsy (CNB) specimens obtained before NAC were available. As controls, CNB specimens from 42 tumors of the hormone… CONTINUE READING

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