Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer

Abstract

1420 OncoImmunology Volume 1 Issue 8 Merkel cell carcinoma (MCC) is a rare and aggressive endocrine skin cancer that is most often found in elderly Caucasian individuals. Treatment of the primary tumor consists in surgery combined or not with radiation therapy. MCC frequently gives rise to distant metastases, the 5 year disease-specific survival being approximately 65%. Immunodeficient patients, including individuals affected by HIV or chronic lymphocytic leukemia as well as transplantation recipients or subjects undergoing immunosuppressive therapy are at a greater risk for MCC compared with the general population. Exposure to sunlight has also been linked to an increased risk for MCC. Rarely, MCC regresses spontaneously, suggesting that activation of the host immune system, at least in a few instances, is sufficient for eradicating the tumor. A majority of MCC lesions were recently found to harbor the DNA of a novel virus, called Merkel cell polyomavirus (MCPyV), de facto suggesting a viral origin for a subset of MCCs. A growing body of evidence indicates that MCPyV is an ubiquitous virus in humans and that it plays a central role in MCC tumorigenesis. MCPyV DNA is clonally integrated into the genome of MCC cells, yet contains mutations that Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer

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@inproceedings{Sihto2012TumorinfiltratingLA, title={Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer}, author={Harri Sihto and Heikki Joensuu}, year={2012} }