Tumor-infiltrating lymphocytes and dendritic cells in human colorectal cancer: their relationship to KRAS mutational status and disease recurrence.

@article{Kocin2011TumorinfiltratingLA,
  title={Tumor-infiltrating lymphocytes and dendritic cells in human colorectal cancer: their relationship to KRAS mutational status and disease recurrence.},
  author={Petr Koci{\'a}n and Monika {\vS}edivcov{\'a} and Jan Drg{\'a}{\vc} and Katerina Cern{\'a} and Jiř{\'i} Hoch and R. Kodet and Jiřina Bartůňkov{\'a} and Radek {\vS}p{\'i}{\vs}ek and Anna Fialov{\'a}},
  journal={Human immunology},
  year={2011},
  volume={72 11},
  pages={
          1022-8
        }
}
The prognosis of newly diagnosed colorectal cancer patients relies mostly on tumor-node metastasis classification. However, analyses of tumor-infiltrating lymphocytes and several molecular markers have also shown promising prognostic value. Mutations in the proto-oncogene KRAS, which occur early in colorectal carcinogenesis, have been demonstrated to be common in human colorectal cancer (CRC); however, their prognostic significance remains controversial. We examined the correlations between… CONTINUE READING
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