Tumor induction by ras and myc oncogenes in fetal and neonatal brain: modulating effects of developmental stage and retroviral dose

@article{Radner2004TumorIB,
  title={Tumor induction by ras and myc oncogenes in fetal and neonatal brain: modulating effects of developmental stage and retroviral dose},
  author={H. Radner and Y. El-Shabrawi and R. Eibl and O. Br{\"u}stle and L. Kenner and P. Kleihues and O. Wiestler},
  journal={Acta Neuropathologica},
  year={2004},
  volume={86},
  pages={456-465}
}
Introduction into fetal rat brain cells of a replication-defective retroviral vector harboring v-Ha-ras and v-gag-myc rapidly causes the induction of highly malignant undifferentiated neuroectodermal tumors following transplantation into the brains of syngeneic hosts [Wiestler, et al. (1992) Cancer Res. 52: 3760–3767]. In the present study, we have investigated the modulating effect of the developmental stage of neural target cells and of the dose of the retroviral vector used in the grafting… Expand
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