Tumor-induced oxidative stress perturbs nuclear factor-kappaB activity-augmenting tumor necrosis factor-alpha-mediated T-cell death: protection by curcumin.

@article{Bhattacharyya2007TumorinducedOS,
  title={Tumor-induced oxidative stress perturbs nuclear factor-kappaB activity-augmenting tumor necrosis factor-alpha-mediated T-cell death: protection by curcumin.},
  author={Sankar Bhattacharyya and Debaprasad Mandal and Gouri Sankar Sen and Suman Pal and Shuvomoy Banerjee and Lakshmishri Lahiry and James Harold Finke and Charles S. Tannenbaum and T. Tandra Das and Gaurisankar Sa},
  journal={Cancer research},
  year={2007},
  volume={67 1},
  pages={362-70}
}
Cancer patients often exhibit loss of proper cell-mediated immunity and reduced effector T-cell population in the circulation. Thymus is a major site of T-cell maturation, and tumors induce thymic atrophy to evade cellular immune response. Here, we report severe thymic hypocellularity along with decreased thymic integrity in tumor bearer. In an effort to delineate the mechanisms behind such thymic atrophy, we observed that tumor-induced oxidative stress played a critical role, as it perturbed… CONTINUE READING

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