Tumor-induced immune dysfunction: the macrophage connection.

  title={Tumor-induced immune dysfunction: the macrophage connection.},
  author={Klaus D. Elgert and David G. Alleva and David W Mullins},
  journal={Journal of leukocyte biology},
  volume={64 3},
Although macrophages (Mphis) mediate tumor cytotoxicity, display tumor-associated antigens, and stimulate antitumor lymphocytes, cancer cells routinely circumvent these host-mediated immune activities, rendering the host incapable of mounting a successful antitumor immune response. Evidence supporting a direct causal relationship between cancer and immune dysfunction suggests that the presence of neoplastic tissue leads to immunologic degeneration. Furthermore, substantial data demonstrate that… CONTINUE READING
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