Tumor-induced disruption of proximal TCR-mediated signal transduction in tumor-infiltrating CD8+ lymphocytes inactivates antitumor effector phase.

@article{VazquezCintron2010TumorinducedDO,
  title={Tumor-induced disruption of proximal TCR-mediated signal transduction in tumor-infiltrating CD8+ lymphocytes inactivates antitumor effector phase.},
  author={Edwin J. Vazquez-Cintron and Ngozi R. Monu and Alan B. Frey},
  journal={Journal of immunology},
  year={2010},
  volume={185 12},
  pages={7133-40}
}
The presence in cancer tissue of Ag-specific, activated tumor infiltrating CD8(+) T cells proves that tumors express Ags capable of eliciting immune response. Therefore, in general, tumor escape from immune-mediated clearance is not attributable to immunological ignorance. However, tumor-infiltrating lymphocytes are defective in effector phase function… CONTINUE READING