Tumor implantation in mouse humerus evokes movement-related hyperalgesia exceeding that evoked by intramuscular carrageenan

@article{Wacnik2003TumorII,
  title={Tumor implantation in mouse humerus evokes movement-related hyperalgesia exceeding that evoked by intramuscular carrageenan},
  author={P. W. Wacnik and Lois J. Kehl and Thomas M. Trempe and Margaret L. R. Ramnaraine and Alvin James Beitz and George L. Wilcox},
  journal={Pain},
  year={2003},
  volume={101},
  pages={175-186}
}

Analgesic effects of loperamide in bone cancer pain in mice

Tumor-evoked sensitization of C nociceptors: a role for endothelin.

It is concluded that ET-1 at the tumor site contributes to tumor-evoked excitation and sensitization of C nociceptors through an ETA receptor mediated mechanism.

Changes in response properties of nociceptive dorsal horn neurons in a murine model of cancer pain.

It is shown that sensitization of WDR neurons, but not HT neurons, contributes to tumor-evoked hyperalgesia, which is often severe and debilitating when cancer metastasizes to bone.

Intrathecal urocortin I in the spinal cord as a murine model of stress hormone‐induced musculoskeletal and tactile hyperalgesia

Data indicate that urocortin I acts at CRF receptors in the mouse spinal cord to elicit a reproducible and persistent tactile and musculoskeletal hyperalgesia, which may serve as a screen for drugs that alleviate painful conditions that are exacerbated by stress.

Cancer pain physiology

Treatments for cancer pain are described in terms of mechanistic insights and in the case of opioids, which modulate pain transmission at spinal and supraspinal sites, their use can be compromised by opioid-induced hyperalgesia.
...

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