Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts.

@article{Lee2005TumorIT,
  title={Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts.},
  author={Jaewoo Lee and Martin Fassnacht and Smita K Nair and David Boczkowski and Eli Gilboa},
  journal={Cancer research},
  year={2005},
  volume={65 23},
  pages={11156-63}
}
Murine studies have shown that immunologic targeting of the tumor vasculature, a key element of the tumor stroma, can lead to protective immunity in the absence of significant pathology. In the current study, we expand the scope of stroma-targeted immunotherapy to antigens expressed in tumor-associated fibroblasts, the predominant component of the stroma in most types of cancer. Mice were immunized against fibroblast activation protein (FAP), a product up-regulated in tumor-associated… CONTINUE READING
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Fibroblast activation protein, a dual Research

  • JE Park, MC Lenter, RN Zimmermann, P Garin-Chesa, LJ Old, WJ. Rettig
  • on July
  • 2005
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