Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity

@article{Chen1994TumorID,
  title={Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity},
  author={Lieping Chen and Patrick McGowan and Sally Ashe and Janet V. Johnston and Yiwen Li and Ingegerd Hellstr{\"o}m and Karl Erik Hellstr{\"o}m},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={179},
  pages={523 - 532}
}
A costimulatory signal through B7 to its counter-receptor CD28 on T cells enhances T cell activation. We have generated recombinant retroviruses containing cDNA for murine B7 and transduced a panel of murine tumor lines with varying immunogenicity to study the effect of B7 costimulation on antitumor immunity. In contrast to the progressive outgrowth of all wild-type (B7-) tumors in unimmunized syngeneic mice, four immunogenic tumors, lymphoma RMA, EL4, mastocytoma P815, and melanoma E6B2… CONTINUE READING

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