Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells

@article{Gao2017TumorIB,
  title={Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells},
  author={Y. Gao and F. Souza-Fonseca-Guimaraes and Tobias Bald and Susanna S. Ng and A. Young and S. Ngiow and J. Rautela and Jasmin Straube and N. Waddell and S. Blake and J. Yan and L. Bartholin and J. Lee and E. Vivier and K. Takeda and M. Messaoudene and L. Zitvogel and M. Teng and G. Belz and C. Engwerda and N. Huntington and K. Nakamura and M. H{\"o}lzel and M. Smyth},
  journal={Nature Immunology},
  year={2017},
  volume={18},
  pages={1004-1015}
}
  • Y. Gao, F. Souza-Fonseca-Guimaraes, +21 authors M. Smyth
  • Published 2017
  • Biology, Medicine
  • Nature Immunology
  • Avoiding destruction by immune cells is a hallmark of cancer, yet how tumors ultimately evade control by natural killer (NK) cells remains incompletely defined. Using global transcriptomic and flow-cytometry analyses and genetically engineered mouse models, we identified the cytokine-TGF-β-signaling-dependent conversion of NK cells (CD49a−CD49b+Eomes+) into intermediate type 1 innate lymphoid cell (intILC1) (CD49a+CD49b+Eomes+) populations and ILC1 (CD49a+CD49b−Eomesint) populations in the… CONTINUE READING

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