Tumor immunity and autoimmunity induced by immunization with homologous DNA.

  title={Tumor immunity and autoimmunity induced by immunization with homologous DNA.},
  author={Lawrence W. Weber and Wilbur B Bowne and Jedd D Wolchok and Roopa Srinivasan and Jie Qin and Yoichi Moroi and Raphael Clynes and Pingfang Song and Jonathan J. Lewis and Alan N. Houghton},
  journal={The Journal of clinical investigation},
  volume={102 6},
The immune system can recognize self antigens expressed by cancer cells. Differentiation antigens are prototypes of these self antigens, being expressed by cancer cells and their normal cell counterparts. The tyrosinase family proteins are well characterized differentiation antigens recognized by antibodies and T cells of patients with melanoma. However, immune tolerance may prevent immunity directed against these antigens. Immunity to the brown locus protein, gp75/ tyrosinase-related protein-1… CONTINUE READING
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Mice lacking CD4 have normal development and function of CD81 cells

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