Tumor immunity: a balancing act between T cell activation, macrophage activation and tumor-induced immune suppression

@article{Sinha2005TumorIA,
  title={Tumor immunity: a balancing act between T cell activation, macrophage activation and tumor-induced immune suppression},
  author={Pratima Sinha and Virginia K. Clements and Seth B Miller and Suzanne Ostrand-Rosenberg},
  journal={Cancer Immunology, Immunotherapy},
  year={2005},
  volume={54},
  pages={1137-1142}
}
The mouse 4T1 mammary carcinoma is a BALB/c-derived tumor that spontaneously metastasizes and induces immune suppression. Although >95% of wild type BALB/c mice die from metastatic 4T1 tumor even if the primary mammary tumor is surgically removed, >65% of BALB/c mice with a deleted Signal Transducer Activator of Transcription 6 (STAT6) gene survive post-surgery. STAT6-deficiency also confers enhanced immunity against spontaneously developing breast cancer since NeuT+/− mice that are STAT6… CONTINUE READING