Tumor immune escape mediated by indoleamine 2,3-dioxygenase.

  title={Tumor immune escape mediated by indoleamine 2,3-dioxygenase.},
  author={Maria Zamanakou and Anastasios E Germenis and Vaios Karanikas},
  journal={Immunology letters},
  volume={111 2},
Amongst the numerous mediators contributing towards the escape of tumors from the host's immune response against them, the enzyme indoleamine 2,3-dioxygenase (IDO) has recently attracted special attention. By catabolizing tryptophan to N-formyl-kynurenine, IDO starves T cells from this important amino acid rendering them incapable of mounting appropriate… CONTINUE READING