Tumor imaging using a standardized radiolabeled adapter protein docked to vascular endothelial growth factor.

@article{Blankenberg2004TumorIU,
  title={Tumor imaging using a standardized radiolabeled adapter protein docked to vascular endothelial growth factor.},
  author={Francis Blankenberg and Stefanie Mandl and Yu-an Cao and Caitlin E O'Connell-Rodwell and Christopher H. Contag and Carina Mar{\'i} and Timur I. Gaynutdinov and J E Vanderheyden and Marina V. Backer and Joseph M Backer},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2004},
  volume={45 8},
  pages={1373-80}
}
UNLABELLED Direct radiolabeling of proteins can result in the loss of targeting activity, requires highly customized procedures, and yields heterogeneous products. Here we describe a novel imaging complex comprised of a standardized (99m)Tc-radiolabeled adapter protein noncovalently bound to a "Docking tag" fused to a "Targeting protein". The assembly of… CONTINUE READING