Tumor-imaging potential of liposomes loaded with In-111-NTA: biodistribution in mice.

@article{Proffitt1983TumorimagingPO,
  title={Tumor-imaging potential of liposomes loaded with In-111-NTA: biodistribution in mice.},
  author={Richard Thomas Proffitt and Lawrence Ernest Williams and Cary Arnett Presant and George Wing-Yiu Tin and Joseph Uliana and Ronald Carl Gamble and John D. Baldeschwieler},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1983},
  volume={24 1},
  pages={
          45-51
        }
}
EMT6 tumors in BALB/c mice have been successfully imaged with small (less than 0.1 mu), unilamellar lipid vesicles (SUVs) loaded with In-111 nitrilotriacetic acid (In-111 NTA). Neutral SUVs prepared from distearoyl phosphatidylcholine (DSPC) and cholesterol (CH) (ratio 2:1) delivered sufficient radioactivity to allow tumor visualization 24 hr after i.v. injection; so did positively and negatively charged SUVs with the ratio 4:1:1 for DSPC:CH:X, were X was stearylamine or dicetyl phosphate… CONTINUE READING

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