Tumor imaging in patients with advanced tumors using a new (99m) Tc-radiolabeled vitamin B12 derivative.

Abstract

UNLABELLED Targeting cancer cells with vitamin B12 (cobalamin) is hampered by unwanted physiologic tissue uptake mediated by transcobalamin. Adhering to good manufacturing practice, we have developed a new (99m)Tc-cobalamin derivative ((99m)Tc(CO)3-[(4-amido-butyl)-pyridin-2-yl-methyl-amino-acetato] cobalamin, (99m)Tc-PAMA-cobalamin). The derivative shows… (More)
DOI: 10.2967/jnumed.113.122499

Topics

7 Figures and Tables

Cite this paper

@article{Sah2014TumorII, title={Tumor imaging in patients with advanced tumors using a new (99m) Tc-radiolabeled vitamin B12 derivative.}, author={B N P Sah and Roger Schibli and Robert J Waibel and Lotta von Boehmer and Peter Blaeuenstein and Ebba Nexo and Anass Johayem and Eliane Fischer and Ennio M{\"u}ller and Jan David Soyka and Alexander K. Knuth and Stefan K Haerle and Pius August Schubiger and Niklaus G. Schaefer and Irene A. Burger}, journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine}, year={2014}, volume={55 1}, pages={43-9} }