Tumor iNOS predicts poor survival for stage III melanoma patients.

  title={Tumor iNOS predicts poor survival for stage III melanoma patients.},
  author={Suhendan Ekmekcioglu and Julie A. Ellerhorst and Victor G Prieto and Marcella M. Johnson and Lyle David Broemeling and Elizabeth Ann Grimm},
  journal={International journal of cancer},
  volume={119 4},
Inducible nitric oxide synthase (iNOS) produces nitric oxide, which has growth promoting activity in melanoma. A preliminary study of tumors from patients with Stage III melanoma who had received neo-adjuvant therapy revealed an association of tumor iNOS expression with shortened survival. The objective of the present study was to determine whether iNOS expression in tumors of newly diagnosed, untreated Stage III patients is predictive of survival. iNOS expression was examined by… CONTINUE READING
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