Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response.

Abstract

Hypoxia is a characteristic feature of locally advanced solid tumors resulting from an imbalance between oxygen (O(2)) supply and consumption. Major causative factors of tumor hypoxia are abnormal structure and function of the microvessels supplying the tumor, increased diffusion distances between the nutritive blood vessels and the tumor cells, and reduced… (More)

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Cite this paper

@article{Vaupel2004TumorHC, title={Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response.}, author={Peter Vaupel and Louis Benjamin Harrison}, journal={The oncologist}, year={2004}, volume={9 Suppl 5}, pages={4-9} }