Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment.

@article{Lee2012TumorhomingPC,
  title={Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment.},
  author={So Jin Lee and Myung Sook Huh and Seung Young Lee and Solki Min and Seulki Lee and Heebeom Koo and Jun-Uk Chu and Kyung Eun Lee and Hyesung Jeon and Yongseok Choi and Kuiwon Choi and Youngro Byun and Seo Jeong and Kinam Park and Kwangmeyung Kim and Ick Chan Kwon},
  journal={Angewandte Chemie},
  year={2012},
  volume={51 29},
  pages={
          7203-7
        }
}
The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization. 
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