Tumor-homing photosensitizer-conjugated glycol chitosan nanoparticles for synchronous photodynamic imaging and therapy based on cellular on/off system.

@article{Lee2011TumorhomingPG,
  title={Tumor-homing photosensitizer-conjugated glycol chitosan nanoparticles for synchronous photodynamic imaging and therapy based on cellular on/off system.},
  author={So Jin Lee and Heebeom Koo and Dong-Eun Lee and Solki Min and Seulki Lee and Xiaoyuan Chen and Yongseok Choi and James F. Leary and Kinam Park and Seo Young Jeong and Ick Chan Kwon and Kwangmeyung Kim and Kuiwon Choi},
  journal={Biomaterials},
  year={2011},
  volume={32 16},
  pages={
          4021-9
        }
}
Herein, we developed the photosensitizer, protoporphyrin IX (PpIX), conjugated glycol chitosan (GC) nanoparticles (PpIX-GC-NPs) as tumor-homing drug carriers with cellular on/off system for photodynamic imaging and therapy, simultaneously. In order to prepare PpIX-GC-NPs, hydrophobic PpIXs were chemically conjugated to GC polymer and the amphiphilic PpIX-GC conjugates formed a stable nanoparticle structure in aqueous condition, wherein conjugated PpIX molecules formed hydrophobic inner-cores… CONTINUE READING
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SHOWING 1-10 OF 28 REFERENCES

FRET quenching of photosensitizer singlet oxygen generation.

  • The journal of physical chemistry. B
  • 2009
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Assessment of the integrity of poly(caprolactone)-b-poly(ethylene oxide) micelles under biological conditions: a fluorogenic-based approach. Langmuir 2006;22:3570e8

R Savi c, T Azzam, A Eisenberg, D. Maysinger
  • 2006
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL