Tumor heterogeneity and stability of the metastatic phenotype of mouse KHT sarcoma cells.

@article{Chambers1981TumorHA,
  title={Tumor heterogeneity and stability of the metastatic phenotype of mouse KHT sarcoma cells.},
  author={A. F. Chambers and Richard Peter Hill and Vincent Ling},
  journal={Cancer research},
  year={1981},
  volume={41 4},
  pages={1368-72}
}
Heterogeneity in metastatic ability has been demonstrated in model systems for in vitro-cloned cell lines for a number of different tumors. We have examined the clonal diversity of mouse KHT sarcoma cells cloned either in vitro or in vivo by determining their ability to form lung colonies following i.v. injection into syngeneic mice. A wide range of metastatic ability was found in both the in vitro- and in vivo-isolated clones, suggesting that the diversity observed is not due to any selection… CONTINUE READING

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