Tumor heterogeneity and progression: conceptual foundations for modeling.

  title={Tumor heterogeneity and progression: conceptual foundations for modeling.},
  author={Larry D. Greller and Frank L. Tobin and George Poste},
  journal={Invasion & metastasis},
  volume={16 4-5},
A conceptual foundation for modeling tumor progression, growth, and heterogeneity is presented. The purpose of such models is to aid understanding, test ideas, formulate experiments, and to model cancer 'in machina' to address the dynamic features of tumor cell heterogeneity, progression, and growth. The descriptive capabilities of such an approach provides a consistent language for qualitatively reasoning about tumor behavior. This approach provides a schema for building conceptual models that… CONTINUE READING
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