Tumor heterogeneity and its implication for drug delivery.

  title={Tumor heterogeneity and its implication for drug delivery.},
  author={Tracy A Denison and You Han Bae},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={164 2},
Evidence continues to accumulate that patient tumors contain heterogeneous cell populations, each of which may contribute differently in extent and mechanism to the progression of malignancy. However, the field of tumor drug delivery research, while continually presenting new and innovative approaches, in many ways continues to operate on the premise that essentially all tumor cells are identical. In some in vivo models, xenograft tumors using cell lines may actually be comparatively… CONTINUE READING

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