Tumor heterogeneity: biological implications and therapeutic consequences

@article{Heppner1983TumorHB,
  title={Tumor heterogeneity: biological implications and therapeutic consequences},
  author={Gloria H. Heppner and Bonnie E. Miller},
  journal={Cancer and Metastasis Reviews},
  year={1983},
  volume={2},
  pages={5-23}
}
It is now appreciated that cancers can be composed of multiple clonal subpopulations of cancer cells which differ among themselves in many properties, including karyotype, growth rate, ability to metastasize, immunological characteristics, production and expression of markers, and sensitivity to therapeutic modalities. Such tumor heterogeneity has been demonstrated in a wide variety of animal tumors of differing etiology, tissue and cellular origin, and species. It has been shown in… CONTINUE READING

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