Tumor growth inhibition in vivo and G2/M cell cycle arrest induced by antisense oligodeoxynucleotide targeting thymidylate synthase.

@article{Berg2001TumorGI,
  title={Tumor growth inhibition in vivo and G2/M cell cycle arrest induced by antisense oligodeoxynucleotide targeting thymidylate synthase.},
  author={Randal W. Berg and Martin Werner and Peter J. Ferguson and Carl O. Postenka and M. Vincent and D James Koropatnick and Ellen N. Behrend},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={298 2},
  pages={477-84}
}
Chemotherapeutic agents targeting thymidylate synthase (TS) are effective against human tumors. Efficacy is limited by drug resistance, often mediated by TS overexpression. Treatment of HeLa cells in vitro with an antisense oligodeoxynucleotide (ODN 83) targeting human TS mRNA reduces TS mRNA and protein levels, inhibits cell proliferation, and sensitizes… CONTINUE READING