Tumor gene expression and prognosis in breast cancer patients with 10 or more positive lymph nodes.

@article{Cobleigh2005TumorGE,
  title={Tumor gene expression and prognosis in breast cancer patients with 10 or more positive lymph nodes.},
  author={Melody A. Cobleigh and Bita Tabesh and Pincas Bitterman and Joffre B. Baker and Maureen Cronin and Mei-lan Liu and Russell Borchik and J. M. Mosquera and Michael G. Walker and Steven Shak},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 24 Pt 1},
  pages={8623-31}
}
PURPOSE This study, along with two others, was done to develop the 21-gene Recurrence Score assay (Oncotype DX) that was validated in a subsequent independent study and is used to aid decision making about chemotherapy in estrogen receptor (ER)-positive, node-negative breast cancer patients. EXPERIMENTAL DESIGN Patients with >or=10 nodes diagnosed from 1979 to 1999 were identified. RNA was extracted from paraffin blocks, and expression of 203 candidate genes was quantified using reverse… CONTINUE READING
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