Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues

@article{Berton2003TumorFI,
  title={Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues},
  author={Thomas R. Berton and Takashi Matsumoto and Angustias Page and Claudio J. Conti and Chu-xia Deng and Jos{\'e} Luis Jorcano and D. B. Johnson},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={5415-5426}
}
The BRCA1 tumor-suppressor protein has been implicated in the regulation of transcription, DNA repair, proliferation, and apoptosis. BRCA1 is expressed in many proliferative tissues and this is at least in part due to E2F-dependent transcriptional control. In this study, inactivation of a conditional murine Brca1 allele was achieved in a variety of epithelial tissues via expression of the Cre recombinase under the control of a keratin 5 (K5) promoter. The K5 Cre:Brca1 conditional knockout mice… CONTINUE READING