Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily.

@article{SteelePerkins2001TumorFA,
  title={Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily.},
  author={G Steele-Perkins and Wei Fang and Xiaohong Helena Yang and Mireille Van Gele and Tobias Carling and Jianren Gu and I M Buyse and Jonathan Alfred Fletcher and Jinyuan Liu and Roderick Bronson and Robert B. Chadwick and Albert de la Chapelle and Xiaohong Zhang and Frank Speleman and S Huang},
  journal={Genes & development},
  year={2001},
  volume={15 17},
  pages={2250-62}
}
The retinoblastoma protein-interacting zinc finger gene RIZ (PRDM2) is a member, by sequence homology, of a nuclear protein-methyltransferase (MTase) superfamily involved in chromatin-mediated gene expression. The gene produces two protein products, RIZ1 that contains a conserved MTase domain and RIZ2 that lacks the domain. RIZ1 gene expression is frequently silenced in human cancers, and the gene is also a common target of frameshift mutation in microsatellite-unstable cancers. We now report… CONTINUE READING
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