Tumor factors predictive of response to hypofractionated radiotherapy in a randomized trial following breast conserving therapy.

@article{Bane2014TumorFP,
  title={Tumor factors predictive of response to hypofractionated radiotherapy in a randomized trial following breast conserving therapy.},
  author={Anita L. Bane and T J Whelan and Gregory R. Pond and Sameer Parpia and Gabriela Gohla and Anthony W. Fyles and J. Pignol and Kathleen I. Pritchard and Stephen Chambers and Mark Norman Levine},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2014},
  volume={25 5},
  pages={992-8}
}
PURPOSE To determine whether tumor grade, molecular subtype and hypoxia predict response to hypofractionated versus standard radiotherapy (RT) following breast-conserving surgery (BCS) for node-negative breast cancer in a randomized controlled trial (RCT). PATIENTS AND METHODS Formalin-fixed paraffin-embedded (FFPE) tumor blocks were available on 989 of 1234 patients enrolled in the Hypofractionation Whole Breast Irradiation (HWBI) Trial. A central pathology review and assessment of tumor… CONTINUE READING
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