Tumor extracellular acidity activated "off-on" release of bortezomib from a biocompatible dendrimer.

Abstract

A nanoparticle with a specific response to tumor extracellular acidity provides a new option in the design of tumor-targeted delivery systems. In this study, we report such a pH-responsive polymer which realizes an "off-on" release of bortezomib in tumor acidic microenvironments. A dendrimer surface is grafted with a neutral shell to reduce its cellular… (More)
DOI: 10.1039/c4bm00365a

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Cite this paper

@article{Wang2015TumorEA, title={Tumor extracellular acidity activated "off-on" release of bortezomib from a biocompatible dendrimer.}, author={Mingming Wang and Yu Wang and Ke Hu and Naimin Shao and Yiyun Cheng}, journal={Biomaterials science}, year={2015}, volume={3 3}, pages={480-9} }