Tumor evasion of the immune system by converting CD4+CD25- T cells into CD4+CD25+ T regulatory cells: role of tumor-derived TGF-beta.

@article{Liu2007TumorEO,
  title={Tumor evasion of the immune system by converting CD4+CD25- T cells into CD4+CD25+ T regulatory cells: role of tumor-derived TGF-beta.},
  author={Victoria C. Liu and Larry Y. Wong and Thomas L. Jang and Ali H. Shah and Irwin I Park and Ximing J. Yang and Qiang Zhang and Scott Lonning and Beverly A Teicher and Chung Ryul Lee},
  journal={Journal of immunology},
  year={2007},
  volume={178 5},
  pages={2883-92}
}
CD4+CD25+ T regulatory (T(reg)) cells were initially described for their ability to suppress autoimmune diseases in animal models. An emerging interest is the potential role of T(reg) cells in cancer development and progression because they have been shown to suppress antitumor immunity. In this study, CD4+CD25- T cells cultured in conditioned medium (CM) derived from tumor cells, RENCA or TRAMP-C2, possess similar characteristics as those of naturally occurring T(reg) cells, including… CONTINUE READING
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