Tumor escape mechanism governed by myeloid-derived suppressor cells.

@article{Nagaraj2008TumorEM,
  title={Tumor escape mechanism governed by myeloid-derived suppressor cells.},
  author={Srinivas Ghante Nagaraj and Dmitry I Gabrilovich},
  journal={Cancer research},
  year={2008},
  volume={68 8},
  pages={2561-3}
}
T-cell nonresponsiveness is a critical factor in immune escape and myeloid-derived suppressor cells play a major role in organizing this phenomenon. Recent findings indicate that myeloid-derived suppressor cells can induce antigen-specific CD8(+) T-cell tolerance through a posttranslation mechanism which involves modification (nitration) of CD8 and the T-cell receptor itself on the T-cell surface. Elucidation of this mechanism of T-cell tolerance offers new opportunities for therapeutic… CONTINUE READING

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