Tumor diversity and evolution revealed through RADseq

@inproceedings{Perry2017TumorDA,
  title={Tumor diversity and evolution revealed through RADseq},
  author={Elizabeth van Buren Perry and Alvin P. Makohon-Moore and Caihong Zheng and Charles K Kaufman and Jun Wang Cai and Christine A Iacobuzio-Donahue and Richard M White},
  booktitle={Oncotarget},
  year={2017}
}
Cancer is an evolutionary disease, and there is increasing interest in applying tools from evolutionary biology to understand cancer progression. Restriction-site associated DNA sequencing (RADseq) was developed for the field of evolutionary genetics to study adaptation and identify evolutionary relationships among populations. Here we apply RADseq to study tumor evolution, which allows for unbiased sampling of any desired frequency of the genome, overcoming the selection bias and cost… CONTINUE READING
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