Tumor-detecting capacity and clinical usefulness of SPIO-MRI in patients with hepatocellular carcinoma

@article{Nakamura2000TumordetectingCA,
  title={Tumor-detecting capacity and clinical usefulness of SPIO-MRI in patients with hepatocellular carcinoma},
  author={Hiroshi Nakamura and Naoki Ito and Fumio Kotake and Yuji Mizokami and Takeshi Matsuoka},
  journal={Journal of Gastroenterology},
  year={2000},
  volume={35},
  pages={849-855}
}
Abstract: The tumor-detecting capacity and clinical usefulness of superparamagnetic iron oxide (SPIO) magnetic resonance imaging (MRI) were examined in patients with hepatocellular carcinoma. The tumor detection rate of SPIO-MRI (64.5%) was comparable to those of dynamic computed tomography (CT) and plain MRI, but lower than that for Gd dynamic MRI (93.5%; P < 0.01%). A combination of Gd dynamic MRI and SPIO-MRI improved the detection rate; further, the tumor stage with respect to tumor blood… 

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References

SHOWING 1-10 OF 22 REFERENCES

[Usefulness of superparamagnetic iron oxide particle (AMI-25) enhanced MR imaging for the diagnosis of liver tumors: comparison with contrast enhanced CT].

SPIO-enhanced MRI may be a promising diagnostic method for the detection of hepatic tumors, especially small ones, and will be more useful than contrast-enhancing CT in the diagnosis of liver tumors.

Detection of hepatic metastases: comparison of contrast-enhanced CT, unenhanced MR imaging, and iron oxide-enhanced MR imaging.

Iron oxide-enhanced MR imaging is a superior imaging technique for the detection of hepatic lesions according to diagnostic accuracy and lesion-liver contrast-to-noise ratios.

Detection of hepatic metastases: ferumoxides-enhanced MR imaging versus unenhanced MR imaging and CT during arterial portography.

Ferumoxides-enhanced MR imaging is more accurate than unenhancing MR imaging and at least as accurate as CTAP for the detection of hepatic metastases.

Liver tumors in cirrhosis: experimental study with SPIO-enhanced MR imaging.

Despite strong impairment of hepatic uptake in cirrhosis, the diagnostic efficacy of MR imaging with SPIO did not seem to be significantly affected.

Detection of liver metastases with superparamagnetic iron oxide in 15 patients: results of MR imaging at 1.5 T.

In this limited study at 1.5 T, the benefit of ferrite enhancement was only marginal when postcontrast images were compared with heavily T2-weighted precontrast scans.

Iron oxide-enhanced MR imaging of the liver and spleen: review of the first 5 years.

Superparamagnetic iron oxide particles are a potent new class of MR contrast agents affording improved detection of hepatic and splenic neoplasms and may extend clinical safety margins through preclinical studies and early clinical results at Massachusetts General Hospital during a 5-year investigation.

Early advanced hepatocellular carcinoma: evaluation of CT and MR appearance with pathologic correlation.

The sensitivity of standard CT for the detection of early advanced HCC was 81%, while that of standard MR imaging was 83%, and a nodule-in-nodule appearance was identified in approximately one-third to one-half of cases.

[Iron oxide-enhanced MR imaging of hepatocellular carcinoma of woodchuck].

To determine the utility of iron oxide-enhanced MR imaging for primary hepatocellular carcinoma (HCC), MR imagings of an adult woodchuck with two nodules of HCC was obtained before and after an

Differentiation of hepatocellular carcinomas from hyperplastic nodules induced in rat liver with ferrite-enhanced MR imaging.

Ferrite-enhanced MR imaging may be useful in differentiating these two lesion types according to their signal intensity changes on images, because Kupffer cells are present in hyperplastic nodular lesions but rarely in hepatocellular carcinomas.

Hepatic tumors: comparison of CT during arterial portography, delayed CT, and MR imaging for preoperative evaluation.

It is concluded that when it is vital to know the precise number, size, and location of focal hepatic lesions before tumor resection, CTAP has the highest sensitivity, but MR imaging is an important adjuvant.