Tumor-detecting capacity and clinical usefulness of SPIO-MRI in patients with hepatocellular carcinoma

  title={Tumor-detecting capacity and clinical usefulness of SPIO-MRI in patients with hepatocellular carcinoma},
  author={Hiroshi Nakamura and Naoki Ito and Fumio Kotake and Yuji Mizokami and Takeshi Matsuoka},
  journal={Journal of Gastroenterology},
Abstract: The tumor-detecting capacity and clinical usefulness of superparamagnetic iron oxide (SPIO) magnetic resonance imaging (MRI) were examined in patients with hepatocellular carcinoma. The tumor detection rate of SPIO-MRI (64.5%) was comparable to those of dynamic computed tomography (CT) and plain MRI, but lower than that for Gd dynamic MRI (93.5%; P < 0.01%). A combination of Gd dynamic MRI and SPIO-MRI improved the detection rate; further, the tumor stage with respect to tumor blood… 

SPIO-Enhanced MRI Findings of Well-Differentiated Hepatocellular Carcinomas: Correlation with MDCT Findings

Most well-differentiated HCCs show hyperintensity on SPIO-enhanced MRI, although the lesions show various CT attenuation patterns.

CT and MR imaging of hepatocellular carcinoma.

This review focuses on the most important findings provided by the unenhanced and dynamic-enhanced CT and MR images regarding HCC evaluation and the various imaging characteristics of HCC at MR imaging after the administration of tissue specific contrast agents.

Superparamagnetic iron oxide-enhanced MR imaging for focal hepatic lesions: a comparison with CT during arterioportography plus CT during hepatic arteriography

The breath-hold SPIO-enhanced MR imaging protocol showed a sensitivity, specificity, and accuracy equivalent to the non-breath-hold MR Imaging protocol and CTAP plus CTHA, which could have the potential to replace CTAPplus CTHa in a certain clinical setting.

Cellular Magnetic Resonance Imaging with Superparamagnetic Iron Oxide: Methods and Applications in Cancer

The characteristics, synthesizing methods, labeling approaches and current applications of SPIO-based cellular MRI in oncology are summarized and current coating materials that render SPIO less toxic and more biocompatible to mammalian cells are outlined.

Magnetic nanoparticle-based cancer nanodiagnostics

The recent progress regarding the types, design, synthesis, morphology, characterization, modification, and the in-vivo and in-Vitro uses of different MRI contrast agents, including MNPs, to diagnose cancer will be the focus of this review.

Imaging Techniques for the Diagnosis of Hepatocellular Carcinoma

This article reviews the test performance of ultrasonography, MRI, and CT for detection of HCC and for evaluation of focal liver lesions as part of a larger review commissioned by the Agency for Healthcare Research and Quality on HCC imaging.

Computed tomography for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease.

An assessment of the accuracy of CT in people with chronic liver disease, who are not included in surveillance programmes or in a clinical setting, is needed for either ruling out or diagnosing hepatocellular carcinoma.

Correlations of MRI manifestations with survivin gene expression in primary hepatic carcinoma.

OBJECTIVE To investigate the correlations of magnetic resonance imaging (MRI) manifestations with survivin gene expression in primary hepatocellular carcinoma (HCC). METHODS A total of 84 HCC

Magnetic resonance molecular imaging with nanoparticles

  • G. LanzaP. Winter S. Wickline
  • Biology, Medicine
    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
  • 2004

The latest developments and projected future applications of these nanotechnology-inspired contrast agents in the field of medical imaging are also discussed.

When compared with other anatomical imag-ing technologies, MRI is nonionizing and has a wider diagnostic range of detection, allowing for both physiological and metabolic studies.



[Usefulness of superparamagnetic iron oxide particle (AMI-25) enhanced MR imaging for the diagnosis of liver tumors: comparison with contrast enhanced CT].

SPIO-enhanced MRI may be a promising diagnostic method for the detection of hepatic tumors, especially small ones, and will be more useful than contrast-enhancing CT in the diagnosis of liver tumors.

Detection of hepatic metastases: comparison of contrast-enhanced CT, unenhanced MR imaging, and iron oxide-enhanced MR imaging.

Iron oxide-enhanced MR imaging is a superior imaging technique for the detection of hepatic lesions according to diagnostic accuracy and lesion-liver contrast-to-noise ratios.

Detection of hepatic metastases: ferumoxides-enhanced MR imaging versus unenhanced MR imaging and CT during arterial portography.

Ferumoxides-enhanced MR imaging is more accurate than unenhancing MR imaging and at least as accurate as CTAP for the detection of hepatic metastases.

Liver tumors in cirrhosis: experimental study with SPIO-enhanced MR imaging.

Despite strong impairment of hepatic uptake in cirrhosis, the diagnostic efficacy of MR imaging with SPIO did not seem to be significantly affected.

Detection of liver metastases with superparamagnetic iron oxide in 15 patients: results of MR imaging at 1.5 T.

In this limited study at 1.5 T, the benefit of ferrite enhancement was only marginal when postcontrast images were compared with heavily T2-weighted precontrast scans.

Iron oxide-enhanced MR imaging of the liver and spleen: review of the first 5 years.

Superparamagnetic iron oxide particles are a potent new class of MR contrast agents affording improved detection of hepatic and splenic neoplasms and may extend clinical safety margins through preclinical studies and early clinical results at Massachusetts General Hospital during a 5-year investigation.

Early advanced hepatocellular carcinoma: evaluation of CT and MR appearance with pathologic correlation.

The sensitivity of standard CT for the detection of early advanced HCC was 81%, while that of standard MR imaging was 83%, and a nodule-in-nodule appearance was identified in approximately one-third to one-half of cases.

[Iron oxide-enhanced MR imaging of hepatocellular carcinoma of woodchuck].

To determine the utility of iron oxide-enhanced MR imaging for primary hepatocellular carcinoma (HCC), MR imagings of an adult woodchuck with two nodules of HCC was obtained before and after an

Differentiation of hepatocellular carcinomas from hyperplastic nodules induced in rat liver with ferrite-enhanced MR imaging.

Ferrite-enhanced MR imaging may be useful in differentiating these two lesion types according to their signal intensity changes on images, because Kupffer cells are present in hyperplastic nodular lesions but rarely in hepatocellular carcinomas.

Hepatic tumors: comparison of CT during arterial portography, delayed CT, and MR imaging for preoperative evaluation.

It is concluded that when it is vital to know the precise number, size, and location of focal hepatic lesions before tumor resection, CTAP has the highest sensitivity, but MR imaging is an important adjuvant.